Role of peptidomimetics for new drug discovery

The art of transforming peptides into drug leads is still a powerful and fertile field in medicinal chemistry discovery. Peptidomimetics can respond to peptide limitations by displaying higher metabolic stability, good bioavailability increasing receptor affinity selectivity. Various synthetic approaches strategies have been developed over the years order modulate conformational flexibility nature mimetic compounds. This review aims outline useful tools towards design, spanning from local modifications, global restrictions use secondary structure mimetics. Key learning points: Advantages peptidomimetics peptides, definition classification mimetics, molecules for Applications mimetics Selected best examples each approach are presented document relevance new